MUC 6 ( mucin 6 , oligomeric mucus / gel - forming )
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چکیده
منابع مشابه
Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B.
Respiratory mucus contains a mixture of gel-forming mucins but the functional significance of these different mucin species is unknown. To help gain a better understanding of mucus in airways we therefore need to ascertain the concentration of each of the gel-forming mucins within respiratory secretions. Thus the aim of this study was to determine the amounts of specific gel-forming mucins dire...
متن کاملMuc5b and Muc5ac are the major oligomeric mucins in equine airway mucus.
Horses frequently suffer from respiratory diseases, which, irrespective of etiology, are often associated with airway mucus accumulation. Studies on human airways have shown that the key structural components of the mucus layer are oligomeric mucins, which can undergo changes of expression and properties in disease. However, there is little information on these gel-forming glycoproteins in hors...
متن کاملThe structure of secreted mucins isolated from the adherent mucus gel: comparison with the gene products.
In the colon there is acontinuous, insoluble adherent mucus gel covering the surface mucosa and forming a protective barrier. The gel forming properties of the mucus barrier are dependent on the component mucins. Mucin subunits consisting of a central protein core with glycosylated and non-glycosylated regions are joined together by disulphide bridges (between the non-glycosylated regions) to f...
متن کاملFast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins
The enormous bacterial load and mechanical forces in colon create a special requirement for protection of the epithelium. In the distal colon, this problem is largely solved by separation of the bacteria from the epithelium by a firmly attached inner mucus layer. In addition, an outer mucus layer entraps bacteria to be cleared by distal transport. The mucus layers contain a network of Muc2 muci...
متن کاملFunction of the CysD domain of the gel-forming MUC2 mucin
The colonic human MUC2 mucin forms a polymeric gel by covalent disulfide bonds in its N- and C-termini. The middle part of MUC2 is largely composed of two highly O-glycosylated mucin domains that are interrupted by a CysD domain of unknown function. We studied its function as recombinant proteins fused to a removable immunoglobulin Fc domain. Analysis of affinity-purified fusion proteins by nat...
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